Polysynaptic Excitatory Postsynaptic Potentials That Trigger Spasms
نویسندگان
چکیده
1 Polysynaptic excitatory postsynaptic potentials that trigger spasms 2 after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. 3 4 Katherine C. Murray, Marilee J. Stephens, Michelle Rank, Jessica D’Amico, 5 Monica A. Gorassini and David J. Bennett 6 Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada 7 8 9 Running Title: 5-HT1 receptors inhibit spasms. 10
منابع مشابه
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Sensory afferent transmission and associated spinal reflexes are normally inhibited by serotonin (5-HT) derived from the brain stem. Spinal cord injury (SCI) that eliminates this 5-HT innervation leads to a disinhibition of sensory transmission and a consequent emergence of unusually long polysynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons. These EPSPs play a critical role in...
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